Search results for: So Dug Lim

Items from 1 to 20 out of 22 results

article

Gliadin intake induces oxidative-stress responses in Caenorhabditis elegans

So Dug Lim, Hyemin Min, Esther Youn, Ichiro Kawasaki, more

Biochemical and Biophysical Research Communications > 2018 > 503 > 3 > 2139-2145

Clinical attention to gluten-related disorders, such as celiac disease and nonceliac gluten sensitivity, is on the rise. However, identifying the pathophysiological mechanisms of gluten-related disorders remains elusive. Gliadin, a component of gluten, is known to play a major role in gluten toxicity. Caenorhabditis elegans has been widely used as the predominant experimental animal model to study...

article

Level of mitoses in non-muscle invasive papillary urothelial carcinomas (pTa and pT1) at initial bladder biopsy is a simple and powerful predictor of clinical outcome: a multi-center study in South Korea

Ji Eun Kwon, Nam Hoon Cho, Yeong-Jin Choi, So Dug Lim, more

Diagnostic Pathology > 2017 > 12 > 1 > 1-12

Background Histologic grade is the most important predictor of the clinical outcome of non-muscle invasive (Ta, T1) papillary urothelial carcinoma (NMIPUCa), but its ambiguous criteria diminish its power to predict recurrence/progression for individual patients. We attempted to find an objective and reproducible histologic predictor of NMIPUCa that correlates well with the clinical outcome. Methods...

article

Ileal mass‐like lesion induced by Epstein–Barr virus‐associated hemophagocytic lymphohistiocytosis in a patient with aplastic anemia

Kyueng‐Whan Min, Ho Young Jung, Hye Seung Han, Tae Sook Hwang, more

APMIS > 123 > 1 > 81 - 86

Hemophagocytic lymphohistiocytosis (HLH) is a rare life‐threatening hyperinflammatory syndrome characterized by activated macrophages engulfing erythrocytes, leukocytes, platelets, and their precursor cells in bone marrow, liver, spleen, or lymph nodes. We report a case of Epstein–Barr virus (EBV)‐associated HLH unusually presenting as an ileal mass. A 23‐year‐old man presented initially with persistent...

article

Prognostic Significance of Ror2 and Wnt5a Expression in Medulloblastoma

Seung Eun Lee, So Dug Lim, So Young Kang, Sang Bum Suh, more

Brain Pathology > 23 > 4 > 445 - 453

Medulloblastoma (MB) is a clinically and biologically heterogeneous group of tumors, and currently classified into four molecular subgroups (Wnt, Shh, Group 3 and Group 4). Intracellular signaling of the Wnt pathway has been divided into two classes: the “canonical” and the “non‐canonical” signaling pathway. The canonical signaling pathway is a well‐established, β‐catenin‐dependent signaling pathway...

article

Genetic alteration and immunohistochemical staining patterns of ovarian high‐grade serous adenocarcinoma with special emphasis on p53 immnnostaining pattern

Sang Hwa Lee, Hyunkyung Kim, Wook Youn Kim, Hye Seung Han, more

Pathology International > 63 > 5 > 252 - 259

We evaluated p53, KRAS, BRAF and CTNNB1 mutation and p53, WT1, p16 and beta‐catenin expression in 31 ovarian high‐grade serous adenocarcinoma. Twenty‐five (80.6%) tumors contained functional mutations of p53; three frameshift, four nonsense and 19 missense mutations. None of the tumors showed KRAS, BRAF or CTNNB1 mutation. In all 18 tumors with missense mutations, ≥60% of tumor cells were strongly...

article

Association of acute tubular necrosis with gross hematuria in cirrhosis-related immunoglobulin A nephropathy

Jang Soo Han, So Dug Lim, Won Hyeok Choi, Sung Chul Hong, more

Kidney Research and Clinical Practice > 2013 > 32 > 1 > 43-46

Immunoglobulin A (IgA) nephropathy associated with cirrhosis is the most common form of secondary IgA nephropathy (IgAN). Cirrhosis-related IgAN is usually clinically silent with a rare occurrence of gross hematuria, unlike in cases of idiopathic IgAN. Especially, acute tubular necrosis (ATN) associated with gross hematuria is very rare in cirrhosis-related IgAN, although acute renal failure is a...

article

BRAF and RAS Mutations in Follicular Variants of Papillary Thyroid Carcinoma

Ji Young Park, Wook Youn Kim, Tae Sook Hwang, Sang Sook Lee, more

Endocrine Pathology > 2013 > 24 > 2 > 69-76

Follicular variants of papillary thyroid carcinoma (FVPTC), particularly the encapsulated subtype, often cause a diagnostic dilemma. Therefore, many FVPTCs are interpreted as “indeterminate” in preoperative fine-needle aspiration (FNA). The aim of this study was to analyze the genotypic changes in BRAF codons 600 and 601, as well as the N, H, and KRAS codons 12, 13, and 61 in FVPTCs and investigate...

article

Acute oxalate nephropathy caused by ethylene glycol poisoning

Jung Woong Seo, Jong-Ho Lee, In Sung Son, Yong Jin Kim, more

Kidney Research and Clinical Practice > 2012 > 31 > 4 > 249-252

Ethylene glycol (EG) is a sweet-tasting, odorless organic solvent found in many agents, such as anti-freeze. EG is composed of four organic acids: glycoaldehyde, glycolic acid, glyoxylic acid and oxalic acid in vivo. These metabolites are cellular toxins that can cause cardio-pulmonary failure, life-threatening metabolic acidosis, central nervous system depression, and kidney injury. Oxalic acid is...

article

Clinical features and pathological characteristics of amygdala enlargement in mesial temporal lobe epilepsy

Dong Wook Kim, Sang Kun Lee, Chun Kee Chung, Young-Cho Koh, more

Journal of Clinical Neuroscience > 2012 > 19 > 4 > 509-512

Although the hippocampus is considered an important site of seizures in mesial temporal lobe epilepsy (mTLE), the amygdala may also have a significant role. Amygdala enlargement is occasionally found in patients with mTLE, and volumetric detection of amygdala enlargement has been documented in “image-negative” patients with TLE. However, only limited data have been reported on the clinical features,...

article

Imaging parameters of high grade gliomas in relation to the MGMT promoter methylation status: the CT, diffusion tensor imaging, and perfusion MR imaging

Won-Jin Moon, Jin Woo Choi, Hong Gee Roh, So Dug Lim, more

Neuroradiology > 2012 > 54 > 6 > 555-563

Introduction We hypothesized that methyl-guanine methyl transferase (MGMT) promoter methylation status, a predictor of the chemosensitivity for high grade gliomas (HGGs), may be associated with computed tomography (CT)/magnetic resonance (MR) imaging variables. Methods Out of 38 consecutive patients with HGGs, 24 patients whose MGMT promoter methylation status was available [12 men and 12 women;...

article

Effects of epidural TNF-α inhibitor injection: analysis of the pathological changes in a rat model of chronic compression of the dorsal root ganglion

Na Ra Kim, Joon Woo Lee, Su Ryoung Jun, In Joon Lee, more

Skeletal Radiology > 2012 > 41 > 5 > 539-545

Objectives To evaluate the efficacy of a single direct epidural injection of tumor necrosis factor (TNF)-α inhibitor to reduce the pathological changes in nerve fiber injuries in a rat model of chronic compression of the dorsal root ganglion (CCD). Materials and methods A surgical procedure for CCD was performed in 17 adult male F-344 rats. The effects of the epidural TNF-α inhibitors on CCD-induced...

article

Osteochondroma of the calcaneus presenting as Haglund's deformity

Hong-Geun Jung, John Alistair Carag, Jae-Yong Park, Eui-Jung Bae, more

Foot and Ankle Surgery > 2011 > 17 > 2 > e20-e22

Haglund's deformity is a symptomatic osseous prominence of the posterosuperior corner of the calcaneus creating posterior heel pain and swelling around the insertion of the Achilles tendon. We have experienced an exceptionally huge Haglund's deformity in a 22-year-old female who initially presented to us with a large painful bony heel mass that had developed over the last decade. We performed the...

article

Tu1524 The Clinical Significance and Etiology of Lymphoid Follicular Proctitis

Junghyun Lee, Byung Kook Kim, So Dug Lim, Kim Jeong Hwan, more

Gastrointestinal Endoscopy > 2011 > 73 > 4(S) > AB436

article

Clevudine myopathy in patients with chronic hepatitis B

Byung Kook Kim, Jeeyoung Oh, So Young Kwon, Won Hyeok Choe, more

Journal of Hepatology > 2009 > 51 > 4 > 829-834

Clevudine (l-FMAU) is a thymidine l-nucleoside analogue that was recently introduced for the treatment of chronic hepatitis B virus infection. Previous studies showed that clevudine has potent and sustained antiviral activity without causing viral resistance. No severe adverse event occurred during clinical trials. We describe two cases of drug-induced myopathy during long-term treatment of chronic...

article

Infectious aneurysmal rupture presenting as massive intracerebral hemorrhage in a preterm baby

Hyun-Seung Kang, So Dug Lim, Young-Cho Koh

Child's Nervous System > 2008 > 24 > 2 > 265-268

Introduction Infectious intracranial aneurysms in infantile period are very rare, and there is no report of infectious intracranial aneurysm in preterm infant Case report A 43-day-old female infant, delivered at 29 weeks of gestation, presented with massive intracranial hemorrhage. Eighteen days after diagnoses of necrotizing enterocolitis, sepsis, and meningitis, the baby became lethargic with...

article

Prognostic role of CD44 cell adhesion molecule expression in primary and metastatic renal cell carcinoma: a clinicopathologic study of 125 cases

So Dug Lim, Andrew N. Young, Gladell P. Paner, Mahul B. Amin

Virchows Archiv > 2008 > 452 > 1 > 49-55

Possible prognostic utility of CD44 in renal cell carcinoma (RCC) prompted a comparison of its expression in primary and metastatic RCC. A total of 164 paraffin-embedded tissues of primary RCC and metastatic RCCs from 125 patients were immunostained with CD44 (standard form) antibody. It consisted of 86 primary RCCs (50 with subsequent metastasis [MET+] and 36 with no known metastasis [MET−]) during...

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Expression of the Neural Stem Cell Markers NG2 and L1 in Human Angiomyolipoma: Are Angiomyolipomas Neoplasms of Stem Cells?

So Dug Lim, William Stallcup, Benjamin Lefkove, Baskaran Govindarajan, more

Molecular Medicine > 2007 > 13 > 3-4 > 160-165

Angiomyolipomas are benign tumors of the kidney which express phenotypes of smooth muscle, fat, and melanocytes. These tumors appear with increased frequency in the autosomal dominant disorder tuberous sclerosis and are the leading cause of morbidity in adults with tuberous sclerosis. While benign, these tumors are capable of provoking life threatening hemorrhage and replacement of the kidney parenchyma,...

article

North American White Mitochondrial Haplogroups in Prostate and Renal Cancer

Lyra M. Booker, Geoffrey M. Habermacher, Benjamin C. Jessie, Qi Carrie Sun, more

The Journal of Urology > 2006 > 175 > 2 > 468-473

While the mitochondrion is known to be a key mediator of apoptosis, there has been little inquiry into the inheritance pattern of mitochondria in patients with cancer. We compared the mtDNA haplotype in patients with prostate and renal cancer to that in controls to determine if there is an association between mitochondrial genotype and cancer. Haplotyping was performed using polymerase chain reaction/digest...

article

A Generally Applicable Method Points to a Novel Role of Platelet-Derived Growth Factor Receptor-β in Tuberous Sclerosis

Jack L. Arbiser, Baskaran Govindarajan, Xianhe Bai, Hiroaki Onda, more

The American Journal of Pathology > 2002 > 161 > 3 > 781-786

Tumors often exhibit activation of specific tyrosine kinases, which may allow targeting of therapy through inhibition of tyrosine kinase signaling. This strategy has been used successfully in the development of STI571 (gleevec), an inhibitor of bcr-abl tyrosine kinase that has been used successfully in the treatment of chronic myelogenous leukemia. STI571 also shows activity against c-kit and platelet-derived...

article

Comparison of Clinicopathologic Characteristics and Genetic Alterations Between Microsatellite Instability-Positive and Microsatellite Instability-Negative Sporadic Colorectal Carcinomas in Patients Younger than 40 Years Old

Jae Hee Suh, So-Dug Lim, Jin Cheon Kim, Sook Hee Hong, more

Diseases of the Colon & Rectum > 2002 > 45 > 2 > 219-228

PURPOSE: Many studies have demonstrated that sporadic microsatellite instabilitypositive colorectal cancers share several clinicopathologic features with hereditary nonpolyposis colorectal cancers, including right-sided location, young age of onset, characteristic histomorphologic features, and a good prognosis. The aim of this study was to define distinct clinicopathologic features of sporadic microsatellite...

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Search results for: So Dug Lim

Gliadin intake induces oxidative-stress responses in Caenorhabditis elegans

Level of mitoses in non-muscle invasive papillary urothelial carcinomas (pTa and pT1) at initial bladder biopsy is a simple and powerful predictor of clinical outcome: a multi-center study in South Korea

Ileal mass‐like lesion induced by Epstein–Barr virus‐associated hemophagocytic lymphohistiocytosis in a patient with aplastic anemia

Prognostic Significance of Ror2 and Wnt5a Expression in Medulloblastoma

Genetic alteration and immunohistochemical staining patterns of ovarian high‐grade serous adenocarcinoma with special emphasis on p53 immnnostaining pattern

Association of acute tubular necrosis with gross hematuria in cirrhosis-related immunoglobulin A nephropathy

BRAF and RAS Mutations in Follicular Variants of Papillary Thyroid Carcinoma

Acute oxalate nephropathy caused by ethylene glycol poisoning

Clinical features and pathological characteristics of amygdala enlargement in mesial temporal lobe epilepsy

Imaging parameters of high grade gliomas in relation to the MGMT promoter methylation status: the CT, diffusion tensor imaging, and perfusion MR imaging

Effects of epidural TNF-α inhibitor injection: analysis of the pathological changes in a rat model of chronic compression of the dorsal root ganglion

Osteochondroma of the calcaneus presenting as Haglund's deformity

Tu1524 The Clinical Significance and Etiology of Lymphoid Follicular Proctitis

Clevudine myopathy in patients with chronic hepatitis B

Infectious aneurysmal rupture presenting as massive intracerebral hemorrhage in a preterm baby

Prognostic role of CD44 cell adhesion molecule expression in primary and metastatic renal cell carcinoma: a clinicopathologic study of 125 cases

Expression of the Neural Stem Cell Markers NG2 and L1 in Human Angiomyolipoma: Are Angiomyolipomas Neoplasms of Stem Cells?

North American White Mitochondrial Haplogroups in Prostate and Renal Cancer

A Generally Applicable Method Points to a Novel Role of Platelet-Derived Growth Factor Receptor-β in Tuberous Sclerosis

Comparison of Clinicopathologic Characteristics and Genetic Alterations Between Microsatellite Instability-Positive and Microsatellite Instability-Negative Sporadic Colorectal Carcinomas in Patients Younger than 40 Years Old

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