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One of the unique features of mitochondria is that they have their own genome. Mitochondrial DNA, just like its counterpart in the nucleus, is constantly exposed to damaging agents such as ionizing radiation, environmental toxins, as well as many therapeutic drugs. Mitochondrial DNA is also the main target of endogenous ROS. Oxidative damage and mutations are common in mtDNA. A wide spectrum of pathogenic...
Mitochondria are organelles which, according to the endosymbiosis theory, evolved from purpurbacteria approximately 1.5 billion years ago. One of the unique features of mitochondria is that they have their own genome. Mitochondria replicate and transcribe their DNA semiautonomously. Like nuclear DNA, mitochondrial DNA (mtDNA) is constantly exposed to DNA damaging agents. Regarding the repair of mtDNA,...
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