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Type I interferons (IFNs) are pathogen-induced immunoregulatory cytokines that exert antiviral and anti-proliferative activities through binding to a common cell surface receptor. Among the 17 human IFN subtypes, IFN β binds the IFNAR1/IFNAR2 receptor chains with particularly high affinity and is especially potent in select bioactivities (e.g. anti-proliferative and pro-apoptotic) when compared to...