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The binding of the GABA A /benzodiazepine receptor agonist [ 3 H]flunitrazepam was studied in the hippocampus of rats kindled by daily stimulation of the Schaffer collaterals, using semi-quantitative autoradiography. Two kindled stages were investigated: (i) 24 h after the last generalized tonic-clonic seizure (fully kindled) and (ii) 28 days after the last generalized seizure (long-term)...
We studied the binding of [ 35 S]t-butylbicyclophosphorothionate to the GABA A receptor-mediated chloride channel in the CA1 area and fascia dentata of control and Schaffer collateral kindled rats, by means of semi-quantitative autoradiography. The [ 35 S]t-butylbicyclophosphorothionate binding was determined at three stages during kindling aquisition: (i) after six afterdischarges,...