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The history of transgenesis is marked by milestones such as the development of cellular transdifferentiation, recombinant DNA, genetic modification of target cells, and finally, the generation of simpler genetically modified organisms (e.g. bacteria and mice). The first transgenic fish was developed in 1984, and since then, continuing technological advancements to improve gene transfer have led to...
Cell proliferation is orchestrated through diverse proteins related to calcium (Ca2+) signaling inside the cell. Cellular Ca2+ influx that occurs first by various mechanisms at the plasma membrane, is then followed by absorption of Ca2+ ions by mitochondria and endoplasmic reticulum, and, finally, there is a connection of calcium stores to the nucleus. Experimental evidence indicates that the fluctuation...
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