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An automation system for bioprocess monitoring and control, based on the distributed control system SIMATIC PCS7 and new online sensors, is introduced. The system realizes on-line monitoring of O2 and CO2 concentrations in the exhaust gas, cell density and size during fermentation processes by new instruments. Different fermentation phases can be clearly identified using the newly developed online...
To facilitate the online monitoring and control of a pilot-scale polymerisation reactor, state estimation techniques are investigated. Specifically, a batch-loop reactor is employed for the emulsion polymerisation of methyl methacrylate. The reactor consists of jacketed tubular sections fitted with in-line static mixers, thus providing mixing homogeneity and improved temperature control. A direct...
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