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Key points
Extreme aviation is accompanied by ever‐present risks of hypobaric hypoxia and decompression sickness. Neuroprotection against those hazards is conferred through fractional inspired oxygen () concentrations of 60–100% (hyperoxia).
Hyperoxia reduces global cerebral perfusion (gCBF), increases reactive oxygen species within the brain and leads to cell death within the hippocampus....
A novel semisynthetic scheme was developed to couple amine-reactive labeling reagents to the muramyl peptide tracheal cytotoxin (TCT) without affecting a critical amine group. Tracheal cytotoxin,N-acetylglucosaminyl-1,6-anhydro-N-acetylmuramyl-Ala-γ-Glu-A2pmAla (A2pm, diaminopimelic acid), is released byBordetella pertussis,the etiologic agent of whooping cough. This glycopeptide reproduces the specific...
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