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Objective
Native American (NA) populations have higher rates of rheumatic disease and present with overlapping disease symptoms and nontraditional serologic features, thus presenting an urgent need for better biomarkers in NA diagnostics. This study used a machine learning approach to identify immune signatures that more effectively stratify NA patients with rheumatic disease.
Methods
Adult NA...
Objective
Patients with established rheumatoid arthritis (RA) demonstrate altered immune responses to Epstein‐Barr virus (EBV), but the presence and roles of EBV have not been fully explored during the pre–clinical disease period. This study was undertaken to determine if EBV infection, as evidenced by an altered anti‐EBV antibody response, either plays an important role in driving the development...
In order to identify the combination of antibody-mediated mechanisms of neutralization that result from vaccination with anthrax vaccine adsorbed (AVA), we isolated antibody secreting cells from a single donor seven days after booster vaccination with AVA and generated nine fully human monoclonal antibodies (hmAb) with high specificity for protective antigen (PA). Two of the antibodies were able to...
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