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Biotin synthase is an S-adenosyl-L-methionine (SAM) radical enzyme that inserts sulfur into dethiobiotin to produce biotin. The reaction proceeds through 5′-deoxyadenosyl radical intermediates that become reduced during the sulfur insertion step to give another product of the reaction, 5′-deoxyadenosine. We report that Escherichia coli strains lacking the 5′-methylthioadenosine/S-adenosylhomocysteine...
Biotin synthase is responsible for the synthesis of biotin from dethiobiotin and sulfur. Although the name of the protein implies that it functions as an enzyme, it has been consistently reported that biotin synthase produces <1 molecule of biotin per molecule of protein in vitro. Moreover, the source of the biotin sulfur atom has been reported to be the [2Fe-2S] center of the protein. Biotin synthase...