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Based on pre-mid-20th-century data, the same photoperiod-related birth seasonality previously observed in schizophrenia was also recently found in neural-tube defects and in extreme left-handedness among professional baseball players. This led to a hypothesis implicating maternal melatonin and other mediators of sunlight actions capable of affecting 4th-embryonic-week developments including neural-tube...
People with schizophrenia and children born with neural tube defects both tend to be conceived most often in May–June, about a month before the summer solstice, and least often in November–December, a month before the winter solstice. Such timings, coupled with evidence of cerebral asymmetry deficits in schizophrenia, and evidence that asymmetry development and neural tube closure represent concurrent...
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