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Aim
Loop diuretics and spironolactone are used in patients with hepatic edema, but they are sometimes associated with insufficient responses as well as adverse events. Tolvaptan, a vasopressin type 2 receptor antagonist, was approved for hepatic edema in 2013. A large‐scale post‐marketing surveillance study has been carried out to evaluate the effectiveness and safety of tolvaptan in real‐world clinical...
Plasmids were detected in isolates of an acidothermophilic archaebacterium Thermoplasma acidophilum. One of the plasmids, pTA1, was characterized. The plasmid was a circular DNA of 15.2 kbp. A physical map was constructed using three restriction endonucleases. A copy number of this plasmid was estimated to be 7-13 per cell. The homologous sequence was not found in the chromosomal DNA of the host...
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