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In the biosynthetic pathway of an antitubercular antibiotic d‐cycloserine (d‐CS), O‐ureido‐d‐serine (d‐OUS) is converted to d‐CS. We have previously demonstrated that DcsG, classified into the ATP‐grasp superfamily enzyme, catalyzes the ring formation to generate d‐CS, which is accompanied by the cleavage of a bond in the urea moiety of d‐OUS to remove a carbamoyl group. Although the general ATP‐grasp...
We have recently been successful in cloning a gene cluster necessary for the biosynthesis of d‐cycloserine (d‐CS) from d‐CS‐producing Streptomyces lavendulaeATCC11924. Although dcsD, one of the ORFs located on the gene cluster, encodes a protein homologous to O‐acetylserine sulfhydrylase that synthesizes l‐cysteine using O‐acetyl‐l‐serine together with sulfide, it functions to form O‐ureido‐l‐serine...
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