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Both cross-sectional and longitudinal epidemiological studies have convincingly established that low plasma levels of testosterone and sex hormone binding globulin (SHBG) are correlated with / predict the metabolic syndrome and diabetes mellitus. Visceral obesity with its associated hyperinsulinism suppresses SHBG synthesis and, concomitantly, circulating testosterone levels. It also may impair the...
Abstract. Receptor activator of nuclear factor (NF-B) ligand (RANKL), its cellular receptor, receptor activator of NF-B (RANK), and the decoy receptor osteoprotegerin (OPG) constitute a novel cytokine system. RANKL produced by osteoblastic lineage cells and activated T lymphocytes is the essential factor for osteoclast formation, fusion, activation, and survival, thus resulting in bone resorption...
Leptin, the ob gene product, has been proposed as a mediator of inflammatory cytokine-dependent decreased food intake and cachexia in rodents. In humans, leptin serum levels increase after administration of tumor necrosis factor-alpha (TNF-α) or interleukin-2 or during septicemia. However, the effect of human chronic inflammatory disease on serum leptin is unknown. We therefore determined the serum...
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