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In a novel attempt to understand the variations in DNA sequences underlying HLA class I alleles associated with HPV16‐related CaCx, we determined the alleles by reconstructing SNP‐based haplotypes from resequencing of the most polymorphic exons 2 and 3 of HLA‐A, HLA‐B and HLA‐C. We also determined the impact of SNPs and transcriptional alterations of the genes on CaCx. A high density of SNPs was identified...
We tested the hypothesis that cervical cancers (CaCx) harbor high HPV16 viral load compared to controls and this is influenced by E2 status and age of subjects. Viral load (natural log transformed values) per 100ng genomic DNA was estimated (152 cases and 87 controls) by Taqman assay. Median viral load was significantly higher (Mann–Whitney U test) among cases (17.21) compared to controls (9.86),...
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