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In most cells, the inactive dimeric NF-κB complexes are retained in the cytoplasm by binding to a group of inhibitory proteins, IκB. In response to extracellular stimuli, IκB is rapidly phosphorylated and degraded, thus, liberating the active NF-κB. To investigate the mechanisms involved, we have developed a cell-free system to study the degradation of the prototype IκB protein, IκBα. In this in vitro...