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We examined the mechanism of 17β-estradiol (estrogen)-mediated inhibition of apoptosis in C6 (rat glioma) cells following exposure to hydrogen peroxide (H 2 O 2 ). Cells were preincubated with 4 μM estrogen for 2 h and then exposed to 100 μM H 2 O 2 for 24 h. Exposure to H 2 O 2 caused significant increases in intracellular calcium (Ca 2+ ...
Compounds formed by 5-nitrofuran with hydrazides of formic, acetic and propionic acids, hereafter respectively known as SBF, SBA and SBP have been used to evaluate the differentiation-inducing properties on two established myeloid leukaemic cell lines ML-2 and EOL-1. SBP is found to be the most effective as an antineoplastic agent amongst the three. Induction of differentiation observed are in the...
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