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ObjectiveTo develop a constitutively active K+ leak channel using TREK‐1 (TWIK‐related potassium channel 1; TREK‐M) that is resistant to compensatory down‐regulation by second messenger cascades, and to validate the ability of TREK‐M to silence hyperactive neurons using cultured hippocampal neurons. To test if adenoassociated viral (AAV) delivery of TREK‐M could reduce the duration of status epilepticus...
Neurons are polarized cells that have a complex and unique morphology: long processes (axons and dendrites) extending far from the cell body. In addition, the somatodendritic and axonal domains are further divided into specific subdomains, such as synapses (pre- and postsynaptic specializations), proximal and distal dendrites, axon initial segments, nodes of Ranvier, and axon growth cones. The striking...
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