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Umbilical cord blood (UCB) is a highly valuable but low-quantity source of hematopoietic stem cells (HSCs) for life-saving transplantations. Recently in Nature Medicine, Guo et al. (2018) found that antagonism of a glycolysis-blocking pathway enhances ex vivo expansion of long-term HSCs from human UCB.
T cells recognize cancer cells via HLA/peptide complexes, and class I HLA-restricted tumor infiltrating T cells correspond to favorable prognosis in ovarian cancer, the most deadly gynecologic disease. The identification of tumor-marking HLA/peptide complexes empowers bourgeoning cancer immunotherapy strategies such as therapeutic vaccination or transgenic T cell therapy. While predictive algorithms...
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