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We have employed deuterium NMR techniques to determine the dynamics of trimethoprim (TMP) in a binary complex with dihydrofolate reductase (DHFR) or in a ternary complex with DHFR and cofactor NADP + in the fully hydrated state. TMP was deuterated at the following positions: (2 ,6 -D 2 )TMP, (3 -Ome-D 3 )TMP and (3 ,4 -Ome-D 6 )TMP. Dynamics of TMP were deduced...