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Introduction: Heat shock protein 65 (hsp65) and a derived peptide, p277, are autoantigens reported in IDDM. I.p. injection of hsp65 reduced diabetes incidence in NOD mice and administration of p277 cured already diabetic mice. Also intrathymic administration of whole islets or GAD65 has been shown to prevent diabetes in NOD mice. The aim of this study was to evaluate whether i.t. injection of mycobacterial...
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