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Glycans exist in nature in various forms of glycoconjugates, i.e., glycoproteins, glycolipids, and glycosaminoglycans, either in soluble or membrane‐bound forms. One of their prominent properties distinguished from nucleic acids and proteins is “heterogeneity” largely attributed to their inherent features of biosynthesis. In general, various methods based on the physicochemical principles have been...
Detection of cancer at early stages that can be treated through surgery is a difficult task. One methodology for cancer biomarker discovery exploits the fact that glycoproteins produced by cancer cells have altered glycan structures, although the proteins themselves are common, ubiquitous, abundant, and familiar. However, as cancer tissue at the early stage probably constitutes less than 1% of the...
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