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Hintergrund Die Studie Stimulation of the Anterior Nucleus of Thalamus for Epilepsy (SANTE) ist bislang die einzige klinische Arbeit, die die Effizienz der tiefen Hirnstimulation (THS) bei Epilepsien mit Evidenzklasse 1 untersucht hat. Weiterhin fehlen Stratifizierungen möglicher Responder bzw. potenzieller Kontraindikationen. Ziel der Arbeit Rationale sowie Design eines doppeltverblindeten und...
The lateral habenular complex (LHb) of the epithalamus is part of a dorsal diencephalic conduction system connecting basal forebrain with regulatory midbrain nuclei. The LHb has been implicated in the regulation of ascending monoaminergic transmission, particularly midbrain dopaminergic neuronal activity. Here, we have investigated whether the LHb in turn is subject to dopaminergic modulation. Alterations...
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