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Long-lasting Ca 2+ (Ca L ) channels of the Ca v 1.2 gene family are heteromultimeric structures that are minimally composed of a pore-forming α 1C subunit and regulatory β and α 2 δ subunits in vascular smooth muscle cells. The Ca L channels are the primary pathways for voltage-gated Ca 2+ influx that trigger excitation–contraction coupling in...
Intracerebroventricular (ICV) injection of streptozotocin (STZ) causes cognitive impairment in rats. ICV STZ is known to impair cholinergic neurotransmission by decreasing choline acetyltransferase (ChAT) levels, glucose and energy metabolism in brain and synthesis of acetyl CoA. However, no reports are available regarding the cholinesterase inhibitors in this model. In aging brain, reduced energy...
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