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Ras pathway signaling plays a critical role in cell growth control and is often upregulated in human cancer. The Raf kinases selectively interact with GTP-bound Ras and are important effectors of Ras signaling, functioning as the initiating kinases in the ERK cascade. Here, we identify a route for the phospho-inhibition of Ras/Raf/MEK/ERK pathway signaling that is mediated by the stress-activated...
K-Ras and H-Ras share identical effectors and have similar properties; however, the high degree of tumor-type specificity associated with K-Ras and H-Ras mutations suggests that they have unique roles in oncogenesis. Here, we report that oncogenic K-Ras, but not H-Ras, suppresses non-canonical Wnt/Ca2+ signaling, an effect that contributes strongly to its tumorigenic properties. K-Ras does this by...
ATP competitive inhibitors of the BRAF V600E oncogene paradoxically activate downstream signaling in cells bearing wild-type BRAF (BRAF WT ). In this study, we investigate the biochemical mechanism of wild-type RAF (RAF WT ) activation by multiple catalytic inhibitors using kinetic analysis of purified BRAF V600E and RAF WT enzymes. We show that activation of...
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