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The cyclic tetrapeptide, HC-toxin, a host-selective toxin and virulence factor produced by the fungal pathogen Cochliobolus carbonum, alkylated a number of bionucleophiles, including guanosine, guanosine-5'-monophosphate, poly d(GC) and DNA from maize genotypes that are susceptible or resistant to the pathogen. The toxin selectively altered in vivo protein synthesis in susceptible genotypes. Treatment...