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A Belgian group has tested the salts of five metals which have been associated with dermal and respiratory sensitization in the mouse local lymph node assay (LLNA). The animals were treated on the skin of both ears three times/day for 3 days. Positive sensitization responses were recorded for cobalt chloride, disodium hexachloroplatinate and potassium dichromate, while beryllium sulfate and nickel...
The murine local lymph node assay (LLNA) has been proposed as a predictive test for the identification of sensitizing agents. We used this test to compare the sensitization potential of NiSO 4 , K 2 Cr 2 O 7 , CoCl 2 , Na 2 PtCl 6 and BeSO 4 , salts of metals which have all been associated with allergic contact dermatitis and either...
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