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“Walked out this morning, don't believe what I saw/Hundred billion bottles washed up on the shore”–Sting. When looking at the myriad changes in the transcriptome and proteome during the response to DNA damage, it seems like hundreds of billions of bottles might be washing across your computer screen. Focusing on just the proteomics datasets describing the dynamics of protein modifications that occur...
Many different cellular pathways have evolved to protect the genome from the deleterious effects of DNA damage that result from exposure to chemical and physical agents. Among these is a process called transcription-coupled repair (TCR) that catalyzes the removal of DNA lesions from the transcribed strand of expressed genes, often resulting in a preferential bias of damage clearance from this strand...
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