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We tested the hypothesis that specific isoforms of protein kinase C (PKC) are responsible for modulation of Na + current (I Na ) derived from the human cardiac Na + channel using activators and inhibitors selective for specific PKCs. Experimental results demonstrated that I Na suppression was mediated by activation of conventional PKCs (cPKCs) and possibly...
Objective: Although activation of protein kinase C (PKC) modulates the function of normal cardiac myocytes and likely plays a role in the pathogenesis of cardiomyopathic disease states, the molecular basis of PKC expression in human ventricle has not been examined in detail. Methods: We have performed Western analysis and immunohistochemistry on explanted human cardiac tissue from nondiseased and...
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