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Interneurons play a critical role in sculpting neuronal circuit activity and their dysfunction can result in neurological and neuropsychiatric disorders. To temporally structure and balance neuronal activity in the adult brain interneurons display a remarkable degree of subclass-specific plasticity, of which the underlying molecular mechanisms have recently begun to be elucidated. Grafting new interneurons...
Oscillatory giant GABA A receptor-mediated currents recorded from medium spiny neurons (MSNs) of the striatum in vitro are an electrophysiological signature of dysfunctioning dopaminergic synaptic transmission. This is a common early signature of Parkinson's disease in pharmacological and genetic mice models. Recorded from at least 40% of MSNs, these currents are present both after and up...
Genetic variation in neuregulin and its ErbB4 receptor has been linked to schizophrenia, although little is known about how they contribute to the disease process. Here, we have examined conditional Erbb4 mouse mutants to study how disruption of specific inhibitory circuits in the cerebral cortex may cause large-scale functional deficits. We found that deletion of ErbB4 from the two main classes of...
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