Search results for: Yingchao Nie

Items from 1 to 14 out of 14 results

article

The Misshapen subfamily of Ste20 kinases regulate proliferation in the aging mammalian intestinal epithelium

Qi Li, Niraj K. Nirala, Hsi‐Ju Chen, Yingchao Nie, more

Journal of Cellular Physiology > 234 > 12 > 21925 - 21936

The intestinal epithelium has a high rate of cell turn over and is an excellent system to study stem cell‐mediated tissue homeostasis. The Misshapen subfamily of the Ste20 kinases in mammals consists of misshapen like kinase 1 (MINK1), mitogen‐activated protein kinase kinase kinase kinase 4 (MAP4K4), and TRAF2 and NCK interacting kinase (TNIK). Recent reports suggest that this subfamily has a novel...

article

Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth

Qi Li, Niraj K. Nirala, Yingchao Nie, Hsi-Ju Chen, more

Developmental Cell > 2018 > 45 > 4 > 433-449.e6

The intestinal epithelium has a high cell turnover rate and is an excellent system to study stem cell-mediated adaptive growth. In the Drosophila midgut, the Ste20 kinase Misshapen, which is distally related to Hippo, has a niche function to restrict intestinal stem cell activity. We show here that, under low growth conditions, Misshapen is localized near the cytoplasmic membrane, is phosphorylated...

article

How Toll Met Hippo

Yingchao Nie, Y. Tony Ip

Developmental Cell > 2016 > 36 > 3 > 246-248

Toll and Hippo are two seemingly disparate pathways that regulate innate immunity and tissue growth, respectively. Reporting recently in Cell, Liu et al. (2016) tie them together by demonstrating that microbial infection activates Toll, which then signals to both pathways to modulate the antimicrobial response.

article

Bunched and Madm Function Downstream of Tuberous Sclerosis Complex to Regulate the Growth of Intestinal Stem Cells in Drosophila

Yingchao Nie, Qi Li, Alla Amcheslavsky, Juan Carlos Duhart, more

Stem Cell Reviews and Reports > 2015 > 11 > 6 > 813-825

The Drosophila adult midgut contains intestinal stem cells that support homeostasis and repair. We show here that the leucine zipper protein Bunched and the adaptor protein Madm are novel regulators of intestinal stem cells. MARCM mutant clonal analysis and cell type specific RNAi revealed that Bunched and Madm were required within intestinal stem cells for proliferation. Transgenic expression of...

article

The Conserved Misshapen-Warts-Yorkie Pathway Acts in Enteroblasts to Regulate Intestinal Stem Cells in Drosophila

Qi Li, Shuangxi Li, Sebastian Mana-Capelli, Rachel J. Roth Flach, more

Developmental Cell > 2014 > 31 > 3 > 291-304

Similar to the mammalian intestine, the Drosophila adult midgut has resident stem cells that support growth and regeneration. How the niche regulates intestinal stem cell activity in both mammals and flies is not well understood. Here, we show that the conserved germinal center protein kinase Misshapen restricts intestinal stem cell division by repressing the expression of the JAK-STAT pathway ligand...

article

Defining the roles of the baculovirus regulatory proteins IE0 and IE1 in genome replication and early gene transactivation

Nadia Sokal, Yingchao Nie, Leslie G. Willis, Junya Yamagishi, more

Virology > 2014 > 468-470 > Complete > 160-171

IE0 and IE1 of the baculovirus Autographa californica multiple nucleopolyhedrovirus are essential transregulatory proteins required for both viral DNA replication and transcriptional transactivation. IE0 is identical to IE1 except for 54 amino acids at the N-terminus but the functional differences between these two proteins remain unclear. The purpose of this study was to determine the separate roles...

article

Enteroendocrine Cells Support Intestinal Stem-Cell-Mediated Homeostasis in Drosophila

Alla Amcheslavsky, Wei Song, Qi Li, Yingchao Nie, more

Cell Reports > 2014 > 9 > 1 > 32-39

Intestinal stem cells in the adult Drosophila midgut are regulated by growth factors produced from the surrounding niche cells including enterocytes and visceral muscle. The role of the other major cell type, the secretory enteroendocrine cells, in regulating intestinal stem cells remains unclear. We show here that newly eclosed scute loss-of-function mutant flies are completely devoid of enteroendocrine...

article

Autographa californica multiple nucleopolyhedrovirus core gene ac92 (p33) is required for efficient budded virus production

Yingchao Nie, Minggang Fang, David A. Theilmann

Virology > 2011 > 409 > 1 > 38-45

Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ac92 is a core gene encoding a protein associated with occlusion derived virus (ODV), binds human P53 and also has flavin adenine dinucleotide linked sulfhydryl oxidase activity but its role in the virus life cycle is not known. To determine ac92 function a deletion virus (vAc ^92KO ) was generated and transfected Sf9 cells revealed...

article

Deletion of AcMNPV AC16 and AC17 results in delayed viral gene expression in budded virus infected cells but not transfected cells

Yingchao Nie, David A. Theilmann

Virology > 2010 > 404 > 2 > 168-179

This study investigated the combined function of the Autographa californica multiple nucleopolyhedrovirus overlapping genes ac16 (BV/ODV-E26, DA26) and ac17. Ac17 is a late gene and the promoter is within the ac16 open reading frame. A double ac16–ac17 knockout virus was generated to assess the function of each gene independently or together. Loss of ac17 did not affect viral DNA synthesis but budded...

article

Deletion of the AcMNPV core gene ac109 results in budded virions that are non-infectious

Minggang Fang, Yingchao Nie, David A. Theilmann

Virology > 2009 > 389 > 1-2 > 66-74

Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ac109 is a core gene and its function in the virus life cycle is unknown. To determine its role in the baculovirus life cycle, we used the AcMNPV bacmid system to generate an ac109 deletion virus (vAc ¹⁰⁹ ^KO ). Fluorescence and light microscopy showed that transfection of vAc ¹⁰⁹ ^KO results in a single-cell infection...

article

AcMNPV AC16 (DA26, BV/ODV-E26) regulates the levels of IE0 and IE1 and binds to both proteins via a domain located within the acidic transcriptional activation domain

Yingchao Nie, Minggang Fang, David A. Theilmann

Virology > 2009 > 385 > 2 > 484-495

IE0 and IE1 are the primary viral regulatory proteins of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) involved in the transactivation of early genes, stimulation of late gene expression, and viral DNA replication. The protein interactions required for IE0 or IE1 to achieve these varied roles are not well defined, so to identify proteins that interact with IE0 and IE1, tandem affinity...

article

AcMNPV EXON0 (AC141) which is required for the efficient egress of budded virus nucleocapsids interacts with β-tubulin

Minggang Fang, Yingchao Nie, David A. Theilmann

Virology > 2009 > 385 > 2 > 496-504

The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) encoded protein, EXON0 (AC141), is required for the efficient transport of nucleocapsids out of the nucleus for the production of budded virus (BV). To further elucidate the molecular mechanisms by which EXON0 regulates BV production, EXON0 was tagged at the N-terminus with 3× FLAG–6× His. Protein complexes were isolated by tandem affinity...

article

Identification of AcMNPV EXON0 (ac141) domains required for efficient production of budded virus, dimerization and association with BV/ODV-C42 and FP25

Minggang Fang, Yingchao Nie, Xiaojiang Dai, David A. Theilmann

Virology > 2008 > 375 > 1 > 265-276

The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) late gene exon0 (ac141) is required for the efficient production of budded virus (BV). EXON0 interacts with nucleopcapsid protein BV/ODV-C42 and FP25 and enables egress of nucleocapsids from the nucleus to the cytoplasm. This study examines the functional domains of EXON0 that play a role in BV production. Six putative domains of the...

article

Characterization of ORF2 and its encoded protein of the Helicoverpa armigera nucleopolyhedrovirus

Yingchao Nie, Qian Wang, Changyong Liang, Minggang Fang, more

Virus Research > 2006 > 116 > 1-2 > 129-135

The open reading frame 2 (ha2) of the Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus (HaSNPV), a conserved gene in most baculoviruses from lepidopteran insects such as p78/83 of the Autographa californica MNPV, was characterized. It is 1242bp long and potentially encodes a 45.9kDa. Ha2 is conserved among baculoviruses from lepidopteran insects. Ha2 transcripts were detected from 16...

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Keywords

ACMNPV (6)
BACULOVIRUS (6)
INTESTINE (3)
BUDDED VIRUS (2)
DROSOPHILA (2)
IE0 (2)
IE1 (2)
MISSHAPEN (2)
STEM CELLS (2)
AC109 (1)
AC141 (1)
AC16 (1)
AC16 (BV/ODV-E26 DA26) (1)
AC17 (1)
AC92(P33) (1)
AUTOGRAPHA CALIFORNICA MULTIPLE NUCLEOPOLYHEDROVIRUS (ACMNPV) (1)
BINDING DOMAIN (1)
BUNCHED (1)
BV/ODV-E26 (1)
BV/ODV-EC43 (1)
CORE GENE (1)
DA26 (1)
DNA REPLICATION (1)
DOMAIN STRUCTURE (1)
EXON0 (1)
EXON0 (AC141) (1)
GENE EXPRESSION (1)
HA2 (1)
HASNPV (1)
HIPPO (1)
KINASES (1)
LEUCINE ZIPPER (1)
MACO96 (1)
MADM (1)
MAP4K4 (1)
MECHANOSENSING (1)
MEMBRANE (1)
MICROTUBULES (1)
MINK1 (1)
P78/83 (1)
RING FINGER (1)
SF9 (1)
STE20 KINASES (1)
STRUCTURAL PROTEIN (1)
SULFHYDRYL OXIDASE (1)
TAO (1)
TNIK (1)
TRANSACTIVATION (1)
TRANSCRIPTION (1)
TRANSCRIPTION FACTOR (1)
TSC-22 (1)
TUBEROUS SCLEROSIS COMPLEX (1)
VIRAL EGRESS (1)
WARTS (1)
WASP (1)
YORKIE (1)
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Elsevier (12)
Springer (1)
Wiley (1)

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