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Zika virus (ZIKV) can be transmitted sexually between humans. However, it is unknown whether ZIKV replicates in the vagina and impacts the unborn fetus. Here, we establish a mouse model of vaginal ZIKV infection and demonstrate that, unlike other routes, ZIKV replicates within the genital mucosa even in wild-type (WT) mice. Mice lacking RNA sensors or transcription factors IRF3 and IRF7 resulted in...
Herpes simplex virus 1 (HSV-1), a leading cause of genital herpes, infects oral or genital mucosal epithelial cells before infecting the peripheral sensory nervous system. The spread of HSV-1 beyond the sensory nervous system and the resulting broader spectrum of disease are not well understood. Using a mouse model of genital herpes, we found that HSV-1-infection-associated lethality correlated with...
Autophagy is a well-known cell-intrinsic antiviral defense mechanism. Two new studies published in this issue of Cell Host & Microbe (Lu et al., 2016; Park et al., 2016) demonstrate that deletion of autophagy in myeloid cells leads paradoxically to better control of viral infection in vivo through enhanced inflammation, leading to antiviral resistance.
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