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Objective: To determine whether prelabour rupture of the membranes is caused by a generalised reduction in amniotic collagen. Setting: Leeds General Infirmary, UK. Study design: The hydroxyproline content of amnion from 55 women with prelabour rupture of the membranes was compared with that from 50 women whose membranes ruptured during labour and 28 women who were delivered by elective caesarean section...