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Ricin, a toxic glycoprotein from the castor bean, causes myocardial hemorrhage and a decrease in blood pressure. We studied the effects of ricin on myocardial function in the isolated rabbit heart. Rabbits were given 0.22 μg/kg of ricin iv and 48 hr later, the heart was isolated and retrogradely perfused through the aorta with Tyrode's solution. A latex balloon was inserted into the left ventricle...
Both ovariectomy and long-term estrogen therapy alter myocardial contractility. We compared the effects of ovariectomy, with and without estrogen replacement, on cardiac myofibrillar ATPase activities and myosin heavy-chain (MHC) isoforms. Twenty-four female New Zealand rabbits were ovariectomized and were subsequently treated for one week with either estradiol acetate (0.1 mg/0.1 ml sunflower oil)...
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