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Our laboratory reported that Irinophore C™ (IrC™; a lipid-based nanoparticulate formulation of irinotecan) is effective against an orthotopic model of glioblastoma (GBM) and that treatment with IrC™ was associated with vascular normalization within the tumor. Here, the therapeutic effects of IrC™ when used in combination with temozolomide (TMZ) in concurrent and sequential treatment schedules were...
The VPH Hypermodelling framework is a collaborative computational platform providing a complete Problem Solving Environment to execute, on distributed computational architectures, sophisticated predictive models involving patient medical data or specialized repositories. In the CHIC1 project, it will be enhanced to support clinicians in providing prompt personalised cancer treatments. It supports...
Parametric estimation of perfusion using [15O]-H2O is an important biomarker for assessing treatment response in oncology clinical trials involving anti-vascular and anti-angiogenic agents. Traditionally the set of dynamic images are reconstructed independently, followed by post-reconstruction kinetic modelling. This methodology results in sub-optimal and often noisy end point parameters if voxel-by-voxel...
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