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In order to remove the influence of anaesthetic agents on neurological function and to expand the range of imaging tasks available it is preferable to image small animals in an awake state. Accurate activity estimates in awake small animal Positron Emission Tomography rely on the measurement of animal head pose over the time-course of the scan. Pose measurements are then incorporated into the emission...
Bootstrap resampling has been successfully used in estimating statistical properties of PET images by generating a set of statistically equivalent datasets based on one or more original datasets. However, the bootstrap resampling is only valid when the original dataset well represents the underlying distribution. The purpose of this work is to assess the validity of nonparametric bootstrap resampling...
Parametric estimation of perfusion using [15O]-H2O is an important biomarker for assessing treatment response in oncology clinical trials involving anti-vascular and anti-angiogenic agents. Traditionally the set of dynamic images are reconstructed independently, followed by post-reconstruction kinetic modelling. This methodology results in sub-optimal and often noisy end point parameters if voxel-by-voxel...
Incorporation of the resolution modelling component of the scanner during statistical image reconstruction often produces images of improved signal-to-noise ratio (SNR). In our previous work we measured and parameterized the Hi-Rez PET/CT scanner's point spread function (PSF) in image space using printed point source arrays at multiple positions. Here we extend the work to the TruePoint PET/CT and...
Direct application of the expectation maximisation (EM) algorithm to the spatiotemporal maximum likelihood problem results in a convenient separation of the image based problem from the projection based problem. This enables any spatiotemporal 4D image model to be incorporated into MLEM image reconstruction with relative ease, only requiring tailored calculation of the fitting weights. As a preliminary...
A new practical and computationally efficient method for deriving and applying the space-variant blurring component of the system matrix is proposed and applied to the HiRez PET/CT scanner. The point spread function (PSF) was sampled at 14400 locations within the field-of-view (FOV) using an array of 120 18-F printed point sources. An HP printer was modified to print the sources on a sheet of A4 paper...
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