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Increased basal serum tryptase (bsT) levels are a well-described risk factor for Hymenoptera venom–induced anaphylaxis (HVAn) in patients allergic to Hymenoptera venom. Increased bsT levels might also indicate the presence of mastocytosis. In this study we evaluated whether the risk of HVAn increases with increasing mast cell load in patients with mastocytosis.Consecutive patients with different subtypes...