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The autoimmune/inflammatory disorder psoriasis is characterized by keratinocyte proliferation and immune cell infiltration of the skin. TCR+CD3+CD4−CD8− “double negative” (DN) T cells can derive from CD8+ T cells through the down-regulation of CD8. The inhibitory molecule programmed death (PD-)1 is expressed on activated T cells and plays a role in the maintenance of peripheral tolerance. A subset...
Aim
The lives of juvenile leatherback turtles are amongst the most enigmatic of all marine mega‐vertebrates. For these cryptic organisms, ocean models provide important insights into their dispersion from natal sites. Here, corroborated by fisheries bycatch data, we simulate spatio‐temporal variation in hatchling dispersion patterns over five decades from the World's largest leatherback turtle nesting...
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