Search results for: Ching-Kuo Lee

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article

Expression of AHI1 Rescues Amyloidogenic Pathology in Alzheimer’s Disease Model Cells

Lai-Lei Ting, Hsien-Tsung Lu, Shu-Fen Yen, Thi Huong Ngo, more

Molecular Neurobiology > 2019 > 56 > 11 > 7572-7582

A hallmark of Alzheimer’s disease (AD) pathogenesis is the accumulation of extracellular plaques mainly composed of amyloid-β (Aβ) derived from amyloid precursor protein (APP) cleavage. Recent reports suggest that transport of APP in vesicles with huntingtin-associated protein-1 (HAP1) negatively regulates Aβ production. In neurons, HAP1 forms a stable complex with Abelson helper integration site-1...

article

Chemical composition and antioxidant, bactericidal, and matrix metalloproteinase inhibition activity of food-related plant

Chin-Hui Chen, Tsan-Chang Chang, Shih-Ying Chen, Su-Jung Hsu, more

LWT - Food Science and Technology > 2017 > 82 > C > 411-419

The present study aimed to investigate bio-function, focusing the on antioxidant, bactericidal, and matrix metalloproteinase (MMP) regulatory activity, of food-related plants. Bioassay-coupled chromatography and bioassay guiding, the rapid and simple screening method, was used to identify potential antioxidant and bactericidal components from fifty-five food-related plants. Lonicera japonica exhibited...

article

Antiobesity and antihyperlipidaemic effects of Yan-Sheng-Yin in animals and humans

Chi-Han Wu, Chun-Hsu Pan, Ching-Kuo Lee, Ming-Jyh Sheu, more

Journal of Functional Foods > 2016 > 24 > C > 173-182

Yan-Sheng-Yin (YSY), a Chinese natural dietary supplement that promotes good health, is entirely composed of natural foods. Whether YSY is a potential adjuvant intervention for reducing hyperlipidaemia, atherogenesis, or obesity is unclear. This study evaluated the inhibitory effects and mechanisms of YSY for hyperlipidaemia, atherogenesis, and obesity. Experimental results showed that YSY reduced...

article

Roles of AMPK and PPARα in the lipolytic effect of kinsenoside

Kur-Ta Cheng, Yu-Shiou Wang, Hsiu-Chu Chou, Chih-Cheng Chang, more

Phytomedicine > 2015 > 22 > 6 > 641-647

Currently, more than one-third of the global population is overweight or obese, which is a risk factor for major causes of death including cardiovascular disease, numerous cancers, and diabetes. Kinsenoside, a major active component of Anoectochilus formosanus exhibits antihyperglycemic, antihyperliposis, and hepatoprotective effects and can be used to prevent and manage obesity. This study examined...

article

Two New Acidic Diterpenoids from the Heartwood of Pinus massoniana Lamb.

H. Abd. Mohamed, Chin‐Lin Hsieh, Chin Hsu, Ching‐Chuan Kuo, more

Helvetica Chimica Acta > 97 > 8 > 1146 - 1151

A new abietane diterpene, named abietopinoic acid, and a new podocarpane diterpene, named podopinoic acid, were isolated from the acetone extract of the heartwood of Pinus massoniana. Their structures were established as 12‐hydroxy‐7‐oxoabieta‐8,11,13‐trien‐18‐oic acid (1) and 13‐hydroxy‐7‐oxopodocarpane (2) by means of spectroscopic analyses including 2D‐NMR. To the best of our knowledge, this is...

article

Determination of nimetazepam and 7-aminonimetazepam in human urine by using liquid chromatography–tandem mass spectrometry

Kuang-Chuan Wang, Min-Chi Cheng, Chin-Lin Hsieh, Jung-Fa Hsu, more

Forensic Science International > 2013 > 224 > 1-3 > 84-89

We report determination of metabolites of popular drugs of abuse, including nimetazepam and nitrazepam, in urine by using liquid chromatography/mass spectrometry. Nimetazepam and its metabolites, 7-aminonimetazepam and nitrazepam, were extracted by solid-phase extraction using a DAU cartridge. An ammonium acetate buffer solution (pH 4) and a Luna polar-RP column were selected as the mobile and stationary...

article

Heptadecanols from the leaves of Persea americana var. americana

Tzong-Huei Lee, Yow-Fu Tsai, Tzu-Tien Huang, Pi-Yu Chen, more

Food Chemistry > 2012 > 132 > 2 > 921-924

From the leaves of Persea americana var. americana, eleven heptadecanol derivatives were identified. Their structures were elucidated on the basis of spectroscopic analyses. The absolute configurations were determined by chemical reaction, NOESY experiment and further comparison of the optical rotation value with the literature value. Additionally, the ratios of the contents of six heptadecanol derivatives...

article

Ficuschlorins A – D, Lactone Chlorins from the Leaves of Ficus microcarpa

Huan‐You Lin, Hsi‐Lin Chiu, Yu‐Hsuang Lan, Chih‐Ying Tzeng, more

Chemistry & Biodiversity > 8 > 9 > 1701 - 1708

Four new lactone chlorins, ficuschlorins A – D (1–4, resp.), and six known pheophytins were isolated from the leaves of Ficus microcarpa. The structures of these compounds were determined by 1D‐ and 2D‐NMR spectroscopy, and other techniques. New natural pheophytins were rarely obtained. In the past ten years, only three new pheophytins were isolated from natural sources.

article

Antimutagenic Constituents of Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) with Potential Cancer Chemopreventive Activity

Huang-Hui Chen, Wenchang Chiang, Jang-Yang Chang, Ya-Lin Chien, more

Journal of Agricultural and Food Chemistry > 2011 > 59 > 12 > 6444 - 6452

article

Constituents of Polyalthia longifolia var. pendula

Tzong-Huei Lee, Mei-Jhen Wang, Pi-Yu Chen, Tung-Ying Wu, more

Journal of Natural Products > 2009 > 72 > 11 > 1960 - 1963

article

A new flavonol galloylrhamnoside and a new lignan glucoside from the leaves of Koelreuteria henryi Dummer

Tzong-Huei Lee, Yuan-Hsiang Chiang, Chin-Hui Chen, Pi-Yu Chen, more

Journal of Natural Medicines > 2009 > 63 > 2 > 209-214

A new flavonol galloylrhamnoside, kaempferol 3-O-(2″,3″-di-O-galloyl)-α-l-rhamnopyranoside, and a new lignan glycoside, hinokinin 7-O-β-d-glucopyranoside were isolated from the leaves of Koelreuteria henryi, along with 18 known compounds, including six flavonol glycosides (3–8), three lignans (9–11), four chlorophyll derivatives (12–15), two steroids (16, 17), and three aromatic compounds (18–20)...

article

Simultaneous detection and quantitation of highly water-soluble herbicides in serum using ion-pair liquid chromatography–tandem mass spectrometry

Kuang-Chuan Wang, Shih-Ming Chen, Jung-Fa Hsu, Sheaw-Guey Cheng, more

Journal of Chromatography B > 2008 > 876 > 2 > 211-218

We report the simultaneous screening of highly polar, water-soluble, and less-volatile herbicides, including glyphosate, glufosinate, paraquat, and diquat, in serum using liquid chromatography–mass spectrometry. The herbicides were separated by solid-phase extraction using a Strata-XC cartridge. A heptafluorobutyric acid solution was chosen as the mobile phase for ion-pair liquid chromatography. Mass...

article

Flavonoids with iNOS inhibitory activity from Pogonatherum crinitum

Guei-Jane Wang, Yi-Min Chen, Teng-Mao Wang, Ching-Kuo Lee, more

Journal of Ethnopharmacology > 2008 > 118 > 1 > 71-78

Pogonatherum crinitum has long been used as a folk remedy for the treatment of many inflammatory diseases in Taiwan, and till now there is still no report concerning its active principles as well as their pharmacological studies. That prompted us to investigate the bioactive constituents of Pogonatherum crinitum. Two novel chemical entities, luteolin 6-C-β-boivinopyranoside (1) and 6-trans-(2″-O-α-rhamnopyranosyl)ethenyl-5,7,3′,4′-tetrahydroxyflavone...

article

Specific Plant Terpenoids and Lignoids Possess Potent Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus

Chih-Chun Wen, Yueh-Hsiung Kuo, Jia-Tsrong Jan, Po-Huang Liang, more

Journal of Medicinal Chemistry > 2007 > 50 > 17 > 4087 - 4095

article

Prorocentin, a New Polyketide from the Marine Dinoflagellate Prorocentrum l ima

Chung-Kuang Lu, Hong-Nong Chou, Ching-Kuo Lee, Tzong-Huei Lee

Organic Letters > 2005 > 7 > 18 > 3893 - 3896

article

Five New Phenolics from the Roots of Ficus b eecheyana

Tzong-Huei Lee, Yuh-Chi Kuo, Guei-Jane Wang, Yueh-Hsiung Kuo, more

Journal of Natural Products > 2002 > 65 > 10 > 1497 - 1500

article

2,2‘-Diphenyl-1-picrylhydrazyl Radical-Scavenging Active Components from Adlay ( Coix lachryma-jobi L. Var. ma-yuen Stapf) Hulls

Ching-Chuan Kuo, Wenchang Chiang, Guey-Ping Liu, Ya-Lin Chien, more

Journal of Agricultural and Food Chemistry > 2002 > 50 > 21 > 5850 - 5855

article

Diterpenoids from the Leaves of Juniperus c hinensis var. k aizuka

Ching-Kuo Lee, Yu-Shia Cheng

Journal of Natural Products > 2001 > 64 > 4 > 511 - 514

article

Leucadenone A-D, the novel class flavanone from the leaves of Melaleuca leucadendron L.

Ching-Kuo Lee

Tetrahedron Letters > 1999 > 40 > 40 > 7255-7259

The novel β-triketone flavanones, leucadenone A-D, have been isolated from the leaves of M. leucadendron L. The structures of 1-4 were determined by NMR spectral and X-ray analysis.

article

Ursane triterpenoids from leaves of melaleuca leucadendron

Ching-Kuo Lee

Phytochemistry > 1998 > 49 > 4 > 1119-1122

Three novel triterpenoids esters were isolated from the leaves of Melaleucaleucadendron in addition to the five known triterpenes ursolaldehyde, ursolic acid, 2α-hydroxyursolic acid, 3β-cis-p-coumaroyloxy-2α-hydroxyurs-12-en-28-oic acid and 3β-trans-p-coumaroyloxy-2α-hydroxyurs-12-en-28-oic acid. The structures of the new compounds were determined by spectral methods to be 3β-cis-p-coumaroyloxy-2α-hydroxyursa-12,20(30)-dien-28-oic...

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