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LL-Z1271α, a fungal metabolite, dose-dependently inhibited interleukin-1β (IL-1β) production in lipopolysaccharide (LPS)-stimulated human whole blood. Oral administration of LL-Z1271α to LPS-challenged mice caused significant lowering in the IL-1β levels in peritoneal cavity. Data presented suggest that LL-Z1271α inhibits IL-1β production by a novel mechanism as the inhibitory activity was not due...
The presence of positive acute phase proteins within the circulation of rheumatoid arthritis patients suggests that elevated cytokine production associated with this chronic inflammatory disorder initiates the hepatic acute phase response. Cytokines produced at inflammatory lesions are believed to travel via the circulation to the liver where they induce acute phase protein production by hepatocytes...
Tenidap is a novel anti-inflammatory and anti-arthritic agent that lowers intracellular pH and suppresses anion transport when applied to cells in vitro. Both of these parameters are known to influence pro-inflammatory cell function. To investigate whether tenidap can modulate cellular responses to cytokine stimulation, several in vitro cytokine-driven assays were characterized with respect to their...
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