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The synthesis of thymidine dimers in which the natural phosphodiester linkage has been replaced by piperazine (3 -(N(CH 2 CH 2 ) 2 N)-5 , 9 and 3 -(N(CH 2 CH 2 ) 2 N)-CO-4 ,10 ) are described. These new dimers were incorporated into oligodeoxynucleotides on an automated DNA-synthesizer using the phosphoramidite approach. The thermal stability of...