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Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of catecholamines. We have studied the association of recombinant human TH with model membranes by using either liposomes or silica gel beads coated with single phospholipid bilayers (TRANSIL ( R)). The use of TRANSIL beads has allowed the determination of apparent dissociation constants (K d ) for the binding of...