Search results for: Vinod S. Hegade

Items from 1 to 11 out of 11 results

article

The Serum Proteome and Ursodeoxycholic Acid Response in Primary Biliary Cholangitis

Ben Barron‐Millar, Laura Ogle, George Mells, Steven Flack, more

Hepatology > 74 > 6 > 3269 - 3283

Background and Aims Stratified therapy has entered clinical practice in primary biliary cholangitis (PBC), with routine use of second‐line therapy in nonresponders to first‐line therapy with ursodeoxycholic acid (UDCA). The mechanism for nonresponse to UDCA remains, however, unclear and we lack mechanistic serum markers. The UK‐PBC study was established to explore the biological basis of UDCA nonresponse...

article

Management of Fatigue in Primary Biliary Cholangitis

Amardeep Khanna, Vinod S. Hegade, David E. Jones

Current Hepatology Reports > 2019 > 18 > 2 > 127-133

Purpose of Review Fatigue in primary biliary cholangitis patients is a frequently encountered and often debilitating symptom. With no currently approved drug therapies available to target fatigue as a symptom, managing these patients can be very challenging in a day-to-day clinical practise. We have critically appraised currently available evidence on various pharmacological agents trialled in the...

article

Autotaxin, bile acid profile and effect of ileal bile acid transporter inhibition in primary biliary cholangitis patients with pruritus

Vinod S. Hegade, Alexandros Pechlivanis, Julie A. K. McDonald, Douglas Rees, more

Liver International > 39 > 5 > 967 - 975

Background and Aims Pruritus is a common symptom in patients with primary biliary cholangitis (PBC) for which ileal bile acid transporter (IBAT) inhibition is emerging as a potential therapy. We explored the serum metabonome and gut microbiota profile in PBC patients with pruritus and investigated the effect of GSK2330672, an IBAT inhibitor. Methods We studied fasting serum bile acids (BAs), autotaxin...

article

Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study

Vinod S Hegade, Stuart F W Kendrick, Robert L Dobbins, Sam R Miller, more

The Lancet > 2017 > 389 > 10074 > 1114-1123

Up to 70% of patients with primary biliary cholangitis develop pruritus (itch) during the course of their disease. Treatment of pruritus in primary biliary cholangitis is challenging and novel therapies are needed. Ursodeoxycholic acid, the standard first-line treatment for primary biliary cholangitis, is largely ineffective for pruritus. We investigated the efficacy and safety of GSK2330672, a selective...

article

Long-Term Fenofibrate Treatment in Primary Biliary Cholangitis Improves Biochemistry but Not the UK-PBC Risk Score

Vinod S. Hegade, Amardeep Khanna, Lucy J. Walker, Lin-Lee Wong, more

Digestive Diseases and Sciences > 2016 > 61 > 10 > 3037-3044

Background Fenofibrate (FF) has been suggested as a second-line agent in primary biliary cholangitis (PBC) patients who do not achieve adequate biochemical response to ursodeoxycholic acid (UDCA) monotherapy. Limited data exist on FF use beyond 12 months, and its long-term effects are unclear. Aim To study the biochemical outcome of long-term (>12 months) FF treatment in combination with UDCA...

article

BAT117213: Ileal bile acid transporter (IBAT) inhibition as a treatment for pruritus in primary biliary cirrhosis: study protocol for a randomised controlled trial

Vinod S. Hegade, Stuart F. W. Kendrick, Robert L. Dobbins, Sam R. Miller, more

BMC Gastroenterology > 2016 > 16 > 1 > 1-12

Background Pruritus (itch) is a symptom commonly experienced by patients with cholestatic liver diseases such as primary biliary cholangitis (PBC, previously referred to as primary biliary cirrhosis). Bile acids (BAs) have been proposed as potential pruritogens in PBC. The ileal bile acid transporter (IBAT) protein expressed in the distal ileum plays a key role in the enterohepatic circulation of...

article

Complications of cholestasis

Vinod S. Hegade, David E.J. Jones

Medicine > 2015 > 43 > 11 > 666-668

Cholestasis (impairment of, or reduction in, bile flow) can both predispose to the development of chronic liver disease and result in its own specific symptoms. The severity of cholestatic symptoms (which themselves can often impair quality of life) is typically independent of the severity of the underlying liver disease, the link with cholestasis frequently being missed as a result. The most characteristic...

article

Mo1000 A Comparative Study of Cholestatic Pruritus in Primary Biliary Cirrhosis Cohorts From USA, UK and Italy

Vinod S. Hegade, George Mells, Craig Lammert, Brian D. Juran, more

Gastroenterology > 2015 > 148 > 4(S1) > S-1059-S-1060

article

The 4-Hour Rule: Preventing Crowding in the Emergency Department

Vinod S. Hegade, Ruchit Sood, Sulleman Moreea

Annals of Emergency Medicine > 2012 > 60 > 1 > 133

article

Sa1013 Elective Recurrent Day Case Paracentesis for Refractory and Resistant Ascites: A Single Centre Experience in Relation to Renal Dysfunction and Cost Effectiveness

Rishma H. Pandya, Vinod S. Hegade, Paul B. Southern, S. Moreea

Gastroenterology > 2012 > 142 > 5 Supplement 1 > S-946

article

Sa1001 Raised Serum Immunoglobulins in Chronic Hepatitis C: Incidence and Association With Genotype, Liver Fibrosis & Sustained Viral Response

Vinod S. Hegade, Kelly Forrester, Inamul Haq, Paul B. Southern, more

Gastroenterology > 2012 > 142 > 5 Supplement 1 > S-943

Filter options

Publication date

Last 3 years (1)

Close

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

From:

To:
Set your own date range

Keywords

Data set

Elsevier (6)
Springer (3)
Wiley (2)

INFONA - science communication portal

Search results for: Vinod S. Hegade

The Serum Proteome and Ursodeoxycholic Acid Response in Primary Biliary Cholangitis

Management of Fatigue in Primary Biliary Cholangitis

Autotaxin, bile acid profile and effect of ileal bile acid transporter inhibition in primary biliary cholangitis patients with pruritus

Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study

Long-Term Fenofibrate Treatment in Primary Biliary Cholangitis Improves Biochemistry but Not the UK-PBC Risk Score

BAT117213: Ileal bile acid transporter (IBAT) inhibition as a treatment for pruritus in primary biliary cirrhosis: study protocol for a randomised controlled trial

Complications of cholestasis

Mo1000 A Comparative Study of Cholestatic Pruritus in Primary Biliary Cirrhosis Cohorts From USA, UK and Italy

The 4-Hour Rule: Preventing Crowding in the Emergency Department

Sa1013 Elective Recurrent Day Case Paracentesis for Refractory and Resistant Ascites: A Single Centre Experience in Relation to Renal Dysfunction and Cost Effectiveness

Sa1001 Raised Serum Immunoglobulins in Chronic Hepatitis C: Incidence and Association With Genotype, Liver Fibrosis & Sustained Viral Response

Filter options

Publication date

Keywords

Data set

Journal

INFONA - science communication portal

Search results for: Vinod S. Hegade

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Keywords

Data set

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options