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Over the recent decades, Clostridium difficile infection (CDI) has emerged as a global public health threat. Despite growing attention, C. difficile remains a poorly understood pathogen, however, the exquisite sensitivity offered by next generation sequencing (NGS) technology has enabled analysis of the genome of C. difficile, giving us access to massive genomic data on factors such as virulence,...
•Clostridium difficile is a nosocomial pathogen, with different strain types causing disease. •We have generated a snap-shot of C. difficile strain types circulating in Victoria. •The diversity of isolates in Victoria may differ from other parts of the world. •Most strains were toxinotype 0, but toxinotypes V and VIII strains were also found. •Strains were metronidazole and vancomycin sensitive;...
Bacteremia caused by Clostridium difficile is rare. In this report, we describe a case of C. difficile bacteremia caused by an unusual strain of C. difficile. The isolate contained neither toxin A nor B genes, however, binary toxin genes were present (tcdA − , tcdB − , cdtA + , cdtB + ) and a 7.2-kb element unrelated to the PaLoc was found inserted within the PaLoc...
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