Wyniki wyszukiwania dla: Jean-Michel Dayer

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From supernatants to cytokines: a personal view on the early history of IL-1, IL-1Ra, TNF and its inhibitor in rheumatology

Jean-Michel Dayer

Arthritis Research & Therapy > 2018 > 20 > 1 > 1-6

Long-term cell cultures developed early in the twentieth century allowed identification in their supernatants of biological mediators subsequently defined as migration factors, interferons, lymphokines, monokines, cytokines and interleukins. In rheumatology, early in the 1930s, synovial cell cultures revealed two major distinct populations, i.e. synovial fibroblasts and monocyte-macrophages. Discovery...

rozdział

Cell-cell contact in chronic inflammation: the importance to cytokine regulation in tissue destruction and repair

Danielle Burger, Pascale Roux-Lombard, Carlo Chizzolini, Jean-Michel Dayer

Progress in Inflammation Research > Cytokines and Joint Injury > 165-188

In many chronic diseases, inflammation is characterized by the influx into the target tissue of migratory cells such as T and B lymphocytes, dendritic cells, neutrophils and mononuclear phagocytes. This influx of inflammatory cells in the target tissue is associated with the proliferation of invading and resident cells and frequently with destruction and remodeling of the extracellular matrix. In...

artykuł

Transcriptional network profile on synovial fluid T cells in psoriatic arthritis

Ugo Fiocco, Veronica Martini, Benedetta Accordi, Francesco Caso, więcej

Clinical Rheumatology > 2015 > 34 > 9 > 1571-1580

The objective of the study was to quantify the transcriptional profile, as the main T cell lineage-transcription factors on synovial fluid (SF) T cells, in relation to SF cytokines and T cell frequencies (%) of psoriatic arthritis (PsA) patients. Reverse phase protein array was employed to identify interleukin (IL)-23Rp19-, FOXP3- and related orphan receptor gamma T (RORγt)- protein and Janus associated...

artykuł

JAK/STAT/PKCδ molecular pathways in synovial fluid T lymphocytes reflect the in vivo T helper-17 expansion in psoriatic arthritis

Ugo Fiocco, Benedetta Accordi, Veronica Martini, Francesca Oliviero, więcej

Immunologic Research > 2014 > 58 > 1 > 61-69

Looking to the sustained psoriatic arthritis (PsA) joint as a model of local human inflammation, this study was designed to assess the T lymphocyte signal transduction pathways potentially involved in this chronic immune-mediated inflammatory process, as characterized by direct ex vivo analysis of T helper (Th)-17 T effector (Teff) cell phenotypes in synovial fluid (SF) and peripheral blood (PB) of...

artykuł

Blockade of intra-articular TNF in peripheral spondyloarthritis: Its relevance to clinical scores, quantitative imaging and synovial fluid and synovial tissue biomarkers

Ugo Fiocco, Paolo Sfriso, Francesca Oliviero, Francesca Lunardi, więcej

Joint Bone Spine > 2013 > 80 > 2 > 165-170

This open-label study is based on a translational approach with the aim of detecting changes in the clinical condition as well as in imaging and synovial biological markers in both synovial fluid (SF) and synovial tissue (ST) in peripheral spondyloarthritis (SpA) patients following intra-articular (IA) blockade of TNF-α by serial etanercept injections.Twenty-seven SpA patients with resistant knee...

artykuł

Blocage intra-articulaire du TNF dans la spondylarthrite périphérique : sa pertinence par rapport aux scores clinique, à l’imagerie quantitative, et aux biomarqueurs dans le liquide synovial et le tissu synovial

Ugo Fiocco, Paolo Sfriso, Francesca Oliviero, Francesca Lunardi, więcej

Revue du rhumatisme > 2013 > 80 > 2 > 149-156

Cette étude réalisée en ouvert est basée sur une approche translationnelle dans le but de détecter les changements cliniques, à l’imagerie et des biomarqueurs synoviaux dans le liquide synovial (LS) et le tissu synovial (TS) dans la spondyloarthropathie périphérique (SpA) après l’inhibition intra-articulaire (IA) du tumor necrosis factor (TNF)-α par des injections répétées d’etanercept (E).Vingt-sept...

artykuł

Autoinflammatory diseases: How to put the fire inside the body out?

Andrea Doria, Jean-Michel Dayer, Leonardo Punzi

Autoimmunity Reviews > 2012 > 12 > 1 > 1-4

Autoinflammatory diseases (AIDs) are a group of distinct hereditable disorders characterized by unexplained, recurrent episodes of fever and severe inflammation, most commonly involving skin, joints, gut, and eyes. Mutations in inflammasome-related proteins, particularly in NOD-like receptor (NLR) genes, have been strongly associated with the occurrence of AIDs. However, new genes and dysfunctional...

artykuł

Interleukin-6: From identification of the cytokine to development of targeted treatments

Eric Assier, Marie-Christophe Boissier, Jean-Michel Dayer

Joint Bone Spine > 2010 > 77 > 6 > 532-536

Interleukin-6 (IL-6) was identified based on extensive research conducted simultaneously on a variety of topics ranging from hepatocyte production of acute-phase proteins to plasmacytoma growth. IL-6 is a cytokine produced by a broad array of cell types and can exert its effects on virtually all cells. IL-6 can induce cell signaling not only via the classic pathway involving the transmembrane receptor...

artykuł

Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL‐22 and IL‐17 production by human T helper cells

Jean‐Marie Ramirez, Nicolò C. Brembilla, Olivier Sorg, Rachel Chicheportiche, więcej

European Journal of Immunology > 40 > 9 > 2450 - 2459

Ligands of the aryl hydrocarbon receptor (AHR), a transcription factor mediating the effects of dioxin, favor Th17 differentiation and exacerbate autoimmunity in mice. We investigated how AHR ligands affected human T‐cell polarization. We found that the high affinity and stable AHR‐ligand dioxin as well as the natural AHR‐ligand 6‐formylinolo[3,2‐b] carbazole induced the downstream AHR‐target cytochrome...

artykuł

Interleukine-6 : de la découverte de la cytokine au développement d’un traitement ciblé

Eric Assier, Marie-Christophe Boissier, Jean-Michel Dayer

Revue du rhumatisme > 2010 > 77 > Supplement 1 > S16-S22

L’interleukine-6 (IL-6) a été caractérisée après un long travail de recherche mené simultanément par des équipes travaillant sur des sujets aussi différents que la production des protéines de la phase aiguë par les hépatocytes ou la croissance des plasmocytomes. L’IL-6 est une cytokine produite par des types cellulaires très variés et peut exercer son action sur quasiment tous les types cellulaires...

artykuł

Synovial tissue rank ligand expression and radiographic progression in rheumatoid arthritis: observations from a proof-of-concept randomized clinical trial of cytokine blockade

Terence Rooney, Carl K. Edwards, Martina Gogarty, Laura Greenan, więcej

Rheumatology International > 2010 > 30 > 12 > 1571-1580

The objective of the study was to evaluate synovial tissue receptor activator of nuclear factor-κβ ligand (RANKL) and osteoprotegerin (OPG) as biomarkers of disease activity, progressive joint damage, and therapeutic response, during cytokine blockade in rheumatoid arthritis (RA). Patients with active RA entered a randomized open-label 12-month study of anakinra 100 mg/day, administered as monotherapy...

artykuł

High-density lipoproteins inhibit inflammatory pathways in human monocytes activated upon chronic inflammatory conditions by cellular contact with stimulated T cells

Danielle Burger, Lyssia Gruaz, Jean-Michel Dayer

Cytokine > 2009 > 48 > 1-2 > 51

artykuł

Serum levels of tissue inhibitor of metalloproteinase-1 and periarticular bone loss in early rheumatoid arthritis

Eithne Murphy, Pascale Roux-Lombard, Terence Rooney, Oliver FitzGerald, więcej

Clinical Rheumatology > 2009 > 28 > 3 > 285-291

We investigated the relationship between disease activity, serum biological mediators of joint damage, and periarticular bone loss in inflammatory arthritis. Patients with early inflammatory arthritis were recruited from a dedicated early arthritis clinic. At the time of recruitment, all had clinical evidence of synovitis. Patients were assessed at baseline and at 1-year follow-up. Periarticular and...

artykuł

Differential regulation of cytokine production by PI3Kδ in human monocytes upon acute and chronic inflammatory conditions

Nicolas Molnarfi, Karim J. Brandt, Lyssia Gruaz, Jean-Michel Dayer, więcej

Molecular Immunology > 2008 > 45 > 12 > 3419-3427

Deregulated production of cytokines, including IL-1β, IL-6 and TNF plays an important role in chronic inflammation. Relevant to this condition, direct cellular contact with stimulated T cells is a potent inducer of cytokine production in human monocytes/macrophages. We previously demonstrated that PI3Ks regulate differential production of IL-1β and its specific inhibitor secreted IL-1 receptor antagonist...

artykuł

28 IL-21 and IL-15 Regulate Human Natural Killer Cell Receptors

Casimir De Rahm, Sylvie Ferrari-Lacraz, Sabrina Jendly, Gregory Schneiter, więcej

Cytokine > 2007 > 39 > 1 > 8

artykuł

Is IL-1 a good therapeutic target in the treatment of arthritis?

Danielle Burger, Jean-Michel Dayer, Gaby Palmer, Cem Gabay

Best Practice & Research Clinical Rheumatology > 2006 > 20 > 5 > 879-896

Inflammation is an important homeostatic mechanism that limits the effects of infectious agents. However, inflammation might be self-damaging and therefore has to be tightly controlled or even abolished by the organism. Interleukin 1 (IL-1) is a crucial mediator of the inflammatory response, playing an important part in the body's natural responses and the development of pathological conditions leading...

artykuł

Adipose tissue is a regulated source of interleukin-10

Cristiana E. Juge-Aubry, Emmanuel Somm, Agnès Pernin, Navid Alizadeh, więcej

Cytokine > 2005 > 29 > 6 > 270-274

White adipose tissue (WAT) is the source of pro- and anti-inflammatory cytokines and we have recently shown that this tissue is a major source of the anti-inflammatory interleukin (IL)-1 receptor antagonist (IL-1Ra). We now aimed at identifying additional adipose-derived cytokines, which might serve as regulators of IL-1Ra.We demonstrate here for the first time that the antiinflammatory cytokine IL-10...

artykuł

Presence of autoantibodies to apolipoprotein A-1 in patients with acute coronary syndrome further links autoimmunity to cardiovascular disease

Nicolas Vuilleumier, Guido Reber, Richard James, Danielle Burger, więcej

Journal of Autoimmunity > 2004 > 23 > 4 > 353-360

Anti-apolipoprotein A-1 (Apo A-1) autoantibodies were described in autoimmune disorders such as systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) and might be involved in the genesis of arterial and venous thrombotic events. To investigate the presence of these autoantibodies in patients with acute coronary syndrome (ACS) without other features of autoimmunity, we set up an enzyme-linked...

artykuł

Production of intracellular IL-1α, IL-1β, and IL-1Ra isoforms by activated human dermal and synovial fibroblasts - Phenotypic differences between human dermal and synovial fibroblasts

Michel Maret, Rachel Chicheportiche, Jean-Michel Dayer, Cem Gabay

Cytokine > 2004 > 25 > 5 > 193-203

We compared the production of IL-1α, IL-1β, and of IL-1Ra isoforms by cultured human dermal (HDF) and synovial fibroblasts (HSF) in response to IL-1α, TNF-α, or direct T cell membrane contact. IL-1Ra was constitutively present in the cell lysates of cultured HDF and its synthesis increased in stimulated cells, whereas IL-1Ra was present in low amounts in the supernatants. Secreted IL-1Ra (sIL-1Ra)...

artykuł

The process of identifying and understanding cytokines: from basic studies to treating rheumatic diseases

Jean-Michel Dayer

Best Practice & Research Clinical Rheumatology > 2004 > 18 > 1 > 31-45

This is a historical overview seen from a personal angle. It covers the insights made during the past 20 years into the destructive processes of rheumatoid arthritis (RA) related to cytokines. The biochemical knowledge of the matrix components (i.e. collagen) and enzymology (i.e. collagenase) available in the 1950s led to the identification of cells from synovial tissue producing collagenase (fibroblast-like...

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