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We audited the files of 114 postmenopausal women who had been treated with subcutaneous Estrapel (50mg oestradiol implants). Of the 92 women who received more than one implant, the median number of days between implants was 223.5 (range 49–875), with an estimated median time to return to baseline of 311days (range 108–1228). Although oestradiol implants can provide an excellent non-oral treatment...