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There are a growing number of new anticoagulants used as an alternative to warfarin. Surgeons will be confronted with an increasing number of patients who may be on these outpatient medications and must be familiar with their management strategies. The purpose of this review is to examine the mechanisms, monitoring and therapeutic reversal of the non-warfarin antithrombotic agents now so frequently...
Female animals tolerate trauma and hemorrhage better than male animalsANDEstrogen has rapid nongenomic effects that protect organs from damage and attenuate insult–induced inflammationMOREOVERThe survival deficit from trauma and hemorrhage produced in ovariectomized female animals is repaired with administration of exogenous estrogenANDWomen survive injury, sepsis, and trauma-hemorrhage–induced hypoxemia/reperfusion...
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