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Polynucleotides encoding connective tissue growth factor (CTGF) are provided. An exemplary polynucleotide of the invention is shown. Expression vectors containing CTGF polynucleotide and host cells containing such expression vectors are also included in the invention.
During development of the embryonic limb, differentiation of mesenchymal progenitor cells into chondrocytes is regulated by cell shape, extracellular matrix, and growth and differentiation factors. In this study, reconstituted basement membrane (Matrigel) prepared from mouse Englebreth-Holm-Swarm tumor tissue was found to stimulate mesenchymal cell chondrogenesis in vitro and the production of cartilage...
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