Search results for: Gil Klinger

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article

Cardiopulmonary exercise testing in adolescence following extremely premature birth

Nofar Amitai, Patrick Stafler, Hannah Blau, Eytan Kaplan, more

Pediatric Pulmonology > 59 > 4 > 997 - 1005

Background Although extremely premature birth disrupts lung development, adolescent survivors of extreme prematurity show good clinical and physiologic outcomes. Cardiopulmonary limitations may not be clinically evident at rest. Data regarding exercise limitation in adolescents following preterm birth in the postsurfactant era are limited. Research Question What are the long‐term effects of bronchopulmonary...

article

Pregnancy outcomes in women on metformin for diabetes or other indications among those seeking teratology information services

Alice Panchaud, Valentin Rousson, Thierry Vial, Nathalie Bernard, more

British Journal of Clinical Pharmacology > 84 > 3 > 568 - 578

Aims Metformin is used to treat type 2 diabetes, polycystic ovary syndrome associated infertility, and gestational diabetes. This study aims to evaluate the safety of metformin in early pregnancy. Method We evaluated the risk of major birth defects and pregnancy losses in a cohort of pregnant women exposed to metformin during the first trimester for different indications relative to a matched unexposed...

article

Short‐ and long‐term complications of in utero exposure to lamotrigine

Merav Cohen‐Israel, Itai Berger, Einat Y. Martonovich, Gil Klinger, more

British Journal of Clinical Pharmacology > 84 > 1 > 189 - 194

Aims The present study evaluates the effect of antenatal lamotrigine exposure, on short‐ and long‐term paediatric outcome. Methods The study included the children of 83 epileptic women treated with lamotrigine during pregnancy, at a tertiary medical centre between 2004–2014. All newborns were monitored for vital signs, congenital malformations and Finnegan score. In addition, the parents completed...

article

Preterm birth – Epidemiology, consequences and possible interventions

Gil Klinger

Reproductive Toxicology > 2017 > 72 > C > 20-21

article

Rehospitalization Through Childhood and Adolescence: Association with Neonatal Morbidities in Infants of Very Low Birth Weight

Jacob Kuint, Liat Lerner-Geva, Gabriel Chodick, Valentina Boyko, more

The Journal of Pediatrics > 2017 > 188 > C > 135-141.e2

To evaluate the impact of major neonatal morbidities on the risks for rehospitalization in children and adolescents born of very low birth weight.An observational study was performed on data of the Israel Neonatal Network linked together with the Maccabi Healthcare Services medical records. After discharge from the neonatal intensive care unit, 6385 infants of very low birth weight born from 1995...

article

The burden of inflammatory stress and antibiotic treatment in preterm neonates and neuro-developmental outcome

Keren politi, Miri Gelbart, Tamar Steinberg, Gil Klinger

European Journal of Paediatric Neurology > 2017 > 21 > S1 > e11

article

Early detection of hymenal anomalies and variants

Paul Merlob, Gil Klinger

European Journal of Pediatrics > 2015 > 174 > 8 > 1127-1127

article

In Utero Oxcarbazepine and a Withdrawal Syndrome, Anomalies, and Hyponatremia

Asaph Rolnitsky, Paul Merlob, Gil Klinger

Pediatric Neurology > 2013 > 48 > 6 > 466-468

Oxcarbazepine is an antiepileptic agent that has been used during pregnancy, although its safety during pregnancy has not been sufficiently established. This article presents an infant born with renal and cardiac malformations who developed a withdrawal syndrome and hyponatremia following in utero exposure to oxcarbazepine. The infant was born at 35 weeks' gestation by urgent cesarean section to a...

article

Intestinal perforation in very-low-birth-weight infants with necrotizing enterocolitis

Nehama Linder, Naama Hammel, Adriana Hernandez, Elena Fridman, more

Journal of Pediatric Surgery > 2013 > 48 > 3 > 562-567

To identify risk factors for intestinal perforation in very-low-birth-weight (VLBW) infants with necrotizing enterocolitis (NEC).Retrospective case–control study over a 10-year period, using univariate and multivariate logistic regression analyses to compare all VLBW infants treated for perforated NEC, with two age and weight-matched groups: infants with non-perforated NEC and infants without NEC...

article

Perinatal risk factors for bronchopulmonary dysplasia in a national cohort of very-low-birthweight infants

Gil Klinger, Nir Sokolover, Valentina Boyko, Lea Sirota, more

American Journal of Obstetrics and Gynecology > 2013 > 208 > 2 > 115.e1-115.e9

We sought to assess the independent effect of perinatal factors on the risk for bronchopulmonary dysplasia (BPD) in very-low-birthweight infants. This was a population-based observational study. Data were prospectively collected by the Israel Neonatal Network. Multivariable analyses identified independent risk factors for BPD. Of 12,139 infants surviving to a postmenstrual age of 36 weeks, 1663...

article

17α Hydroxyprogesterone caproate for prevention of recurrent spontaneous preterm birth

Paul Merlob, Bracha Stahl, Gil Klinger

Reproductive Toxicology > 2012 > 33 > 1 > 15-19

Use of 17-alpha-hydroxyprogesterone caproate for the prevention of spontaneous preterm birth in women at risk is reviewed. Early studies regarding this topic reached contradicting conclusions, however recent studies showed that weekly injections of 17-alpha-hydroxyprogesterone caproate beginning at 16–20weeks’ gestation resulted in a substantial reduction in the rate of spontaneous recurrent preterm...

article

Targeted fluconazole prophylaxis for high-risk very low birth weight infants

Asaph Rolnitsky, Itzhak Levy, Lea Sirota, Itamar Shalit, more

European Journal of Pediatrics > 2012 > 171 > 10 > 1481-1487

Antifungal prophylaxis is increasingly used in very low birth weight (VLBW) infants who are at risk for severe fungal infections. Our objective was to assess the effectiveness of targeted fluconazole prophylaxis for high-risk VLBW infants. A retrospective cohort study with historical controls was performed. During the period 2007–2008, all high-risk VLBW infants (birth weight, ≤1,000 g; gestational...

article

Preliminary evaluation of the efficacy and safety of an alternative treatment for nausea and vomiting of pregnancy

Liat Ashkenazi-Hoffnung, Paul Merlob, Bracha Stahl, Gil Klinger

Reproductive Toxicology > 2011 > 31 > 2 > 255

article

Neurodevelopmental outcome following in utero exposure to SSRIs

Gil Klinger, Paul Merlob

Reproductive Toxicology > 2011 > 31 > 2 > 252

article

Persistent coagulase-negative staphylococci bacteremia in very-low-birth-weight infants

Nehama Linder, Adriana Hernandez, Limor Amit, Gil Klinger, more

European Journal of Pediatrics > 2011 > 170 > 8 > 989-995

This study sought to expand current knowledge on the clinical and epidemiological characteristics of persistent coagulase-negative Staphylococcus (CoNS) bacteremia in very-low-birth-weight (VLBW) infants. Background and disease-related data were collected prospectively on 143 VLBW infants diagnosed with CoNS bacteremia at a pediatric tertiary medical center in 1995–2003. Findings were compared between...

article

Cerebrospinal fluid lactate dehydrogenase isoenzymes in children with bacterial and aseptic meningitis

Moshe Nussinovitch, Yaron Finkelstein, Keren Politi Elishkevitz, Benjamin Volovitz, more

Translational Research > 2009 > 154 > 4 > 214-218

Differentiation of bacterial from aseptic meningitis may be difficult. Our aim was to determine the pattern of distribution of lactate dehydrogenase (LDH) isoenzymes in the cerebrospinal fluid (CSF) of patients with bacterial and aseptic meningitis. One hundred and fifty-seven patients with suspected meningitis were enrolled in the study. They were divided into 3 groups according to the culture- or...

article

Tetrada of the possible mycophenolate mofetil embryopathy: A review

Paul Merlob, Bracha Stahl, Gil Klinger

Reproductive Toxicology > 2009 > 28 > 1 > 105-108

Mycophenolate mofetil (MFM) is an immunosuppressant agent used in organ transplantation, rheumatoid arthritis and lupus nephritis. Experimental data show that doses roughly equivalent to those used clinically in transplant patients may cause fetal resorption and malformations in pregnant rats and rabbits.There are limited data regarding the use of MFM in pregnant women. The human experience is based...

article

Epidemiology and risk factors for early onset sepsis among very-low-birthweight infants

Gil Klinger, Itzhak Levy, Lea Sirota, Valentina Boyko, more

American Journal of Obstetrics and Gynecology > 2009 > 201 > 1 > 38.e1-38.e6

The purpose of this study was to determine the incidence, causative pathogens, and risk factors for early onset sepsis (EOS) among very-low-birthweight (VLBW) infants.This was a population based observational study. Data were prospectively collected by the Israel Neonatal Network between 1995 and 2005. Multivariable analyses identified independent risk factors for EOS.EOS developed in 383 of 15,839...

article

Congenital heart disease: Correlation with fluctuations in cosmophysical activity, 1995–2005

Elyiahu Stoupel, Einat Birk, Anna Kogan, Gil Klinger, more

International Journal of Cardiology > 2009 > 135 > 2 > 207-210

Environmental physical activity is known to be associated with many factors of human homeostasis, such as fetal development, birth number, and some genetic abnormalities. This study sought to investigate possible temporal links between the occurrence of congenital heart disease and solar, geomagnetic, and cosmic ray activities.The study sample include 79,085 infants born live at a tertiary medical...

article

Crossed sagittal-suture cephalhematoma

Paul Merlob, Gil Klinger

Child's Nervous System > 2009 > 25 > 4 > 397-397

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Search results for: Gil Klinger

Cardiopulmonary exercise testing in adolescence following extremely premature birth

Pregnancy outcomes in women on metformin for diabetes or other indications among those seeking teratology information services

Short‐ and long‐term complications of in utero exposure to lamotrigine

Preterm birth – Epidemiology, consequences and possible interventions

Rehospitalization Through Childhood and Adolescence: Association with Neonatal Morbidities in Infants of Very Low Birth Weight

The burden of inflammatory stress and antibiotic treatment in preterm neonates and neuro-developmental outcome

Early detection of hymenal anomalies and variants

In Utero Oxcarbazepine and a Withdrawal Syndrome, Anomalies, and Hyponatremia

Intestinal perforation in very-low-birth-weight infants with necrotizing enterocolitis

Perinatal risk factors for bronchopulmonary dysplasia in a national cohort of very-low-birthweight infants

17α Hydroxyprogesterone caproate for prevention of recurrent spontaneous preterm birth

Targeted fluconazole prophylaxis for high-risk very low birth weight infants

Preliminary evaluation of the efficacy and safety of an alternative treatment for nausea and vomiting of pregnancy

Neurodevelopmental outcome following in utero exposure to SSRIs

Persistent coagulase-negative staphylococci bacteremia in very-low-birth-weight infants

Cerebrospinal fluid lactate dehydrogenase isoenzymes in children with bacterial and aseptic meningitis

Tetrada of the possible mycophenolate mofetil embryopathy: A review

Epidemiology and risk factors for early onset sepsis among very-low-birthweight infants

Congenital heart disease: Correlation with fluctuations in cosmophysical activity, 1995–2005

Crossed sagittal-suture cephalhematoma

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