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Interferon-alpha (IFN-alpha) is an important drug used in anti-melanoma therapy. However, metastases eventually reappear in almost 60% of melanoma patients, who have received adjuvant cytokine therapy suggesting that IFN-alpha can paradoxically promote disease progression in some cases, at least. In this study, we have investigated the possibility that a growth-promoting STAT3 protein might be activated...
The paper is devoted to the results of biophysical experiments by which the existence of the field of so called pulse vector magnetic potential was successfully proved. The decision to carry out these tests was motivated by a favorable coincidence of pieces of knowledge obtained in the solution of other biophysical-research projects. The aim of the original experiment was only to check whether the...
Negatively supercoiled, relaxed and linearized forms of pSP73 DNA were modified in a cell-free medium by cis-diamminedichloroplatinum(II) (cisplatin). The frequency of interstrand cross-links (ICLs) formed in these DNAs has been determined by several techniques of molecular biophysics. It was found that the amount of the ICLs formed by cisplatin was radically enhanced in negatively or positively supercoiled...
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