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Levels of COX-2 and downstream products, such as prostaglandin (PG) E 2 , are increased in inflammatory settings after stimulation by IL-1β, LPS, and other innate factors. Although the T H 2 cytokines IL-4 and IL-13 have been reported to decrease COX-2 levels in some cell types, neither the effect of these cytokines on other PGE 2 -related pathways nor their effect in primary...
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